A translational model to determine rodent’s age from human foetal age. Transcriptional neoteny in the human brain. Uniquely hominid features of adult human astrocytes. Control of species-dependent cortico-motoneuronal connections underlying manual dexterity. Evolution of the human nervous system function, structure, and development. Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features. Generalizing RNA velocity to transient cell states through dynamical modeling. Focal loss of anterior horn cells in the cervical cord in motor neuron disease. Spinal muscular atrophy: a deficiency in a ubiquitous protein a motor neuron-specific disease. Functional diversity of astrocytes in neural circuit regulation. Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Together with mapping of disease-related genes, this transcriptomic mapping of the developing human spinal cord opens new avenues for interrogating the cellular basis of motor control in humans and guides human stem cell-based models of disease. We also integrated our data with multiple existing datasets of the developing human spinal cord spanning 22 weeks of gestation to investigate the cell diversity over time. Motor neurons clustered at this stage into groups suggestive of alpha and gamma neurons. Glia displayed diversity related to positional identity along the dorso-ventral and rostro-caudal axes, while astrocytes with specialized transcriptional programs mapped into white and gray matter subtypes. Here we transcriptomically profiled the midgestation human spinal cord with single-cell resolution and discovered remarkable heterogeneity across and within cell types. But how this complexity arises at the cellular level in the human spinal cord remains unknown. The human spinal cord is exquisitely organized, and this complex organization contributes to the diversity and intricacy of motor behavior and sensory processing. Netmarble recently acquired social casino developer SpinX Games for $2.19 billion.Understanding spinal cord assembly is essential to elucidate how motor behavior is controlled and how disorders arise. PUBG Mobile developers Krafton’s IPO debut stumbled on an unimpressive first day for the South Korean firm. NCSoft has scheduled a presentation for August 19th, 2021, where more details about the game are expected to be unveiled. The website is currently available in four languages, Korean, Japanese, Traditional Chinese and English, hinting that the game may debut outside of South Korea. Instead, the site showcases several promotional cinematic videos that provide some context regarding the setting and plot of the new entry to the series. The game continues to generate a vast amount of income for the company and was the highest-earning game on Google Play for May 2021.Ī website for the new game is currently operational but does not highlight gameplay features. NCSoft’s Lineage M, a mobile version of the original 1998 MMORPG Lineage, is one of the highest-grossing mobile titles of all time, generating $3.5 billion in its lifetime. Lineage W will be the third main game in the series to arrive on the mobile platform, following Lineage M and Lineage 2: Revolution, a prequel to Lineage 2. Unlike the other games in the series, Lineage W will launch directly on mobile alongside the PC release. NCSoft is best known for developing MMORPGs, such as the Lineage and Guild Wars games. South Korean developer NCSoft has revealed a new title in the Lineage series, Lineage W.Īccording to Siliconera, Lineage W will be similar to predecessors Lineage and Lineage 2 and will be an MMORPG.
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